RGS6 drives cardiomyocyte death following nucleolar stress by suppressing Nucleolin/miRNA-21.

"to generate the protein-protein interaction model between rgs6 and nucleolin the alpha-fold 3d structures available on uniprot database for human rgs6 (id: p49758| https://www uniprot org/uniprotkb/p49758/entry ) and nucleolin (710 amino acids|id: p19338| https://www uniprot org/uniprotkb/p19338/entry ) were used."

"Declarations Ethics approval and consent to participateWe have performed the mouse experiments at the Aryakul College of Pharmacy & Research, Lucknow and All India Institute of Medical Sciences (AIIMS), Bhopal. Animals were obtained post clearances from the Animal Ethics Committee (1896/PO/Re/S/16/CPCSEA/2022/4—Aryakul College of Pharmacy & Research and AIIMS/ BPL/IAEC/2021/030—AIIMS Bhopal) and were handled following International Animal Ethics Committee Guidelines and in agreement with the Guide for the Use and Care of Laboratory Animals (NIH). We have used post-mortem human tissue samples and collected it from the Department of Forensic Medicine, Sagore Dutta Medical College &Hospital, Kolkata, West Bengal post obtaining the ethical clearance from CBMR Ethics Committee (IEC/CBMR/Corr/2020/16/6).Detailed patient information for samples utilized in this work have been provided in the supplementary. Consent for publicationAll the authors gave their consent for publication. Competing interestsThe authors declare that they have no competing interest among authors for this article. Competing interests The authors declare that they have no competing interest among authors for this article."

"Funding This work was supported by internal funds from the CBMR (CBMR/IMR/0012/2021), Uttar Pradesh Government; Indian Council of Medical Research (ICMR-5/4/1–22/CVD/2022-NCD-I) and Department of Science of Technology (SERB-CRG/2022/003455) to BM."