A retrospective study on adverse events of intravenous administration of sulfur hexafluoride microbubbles in abdominal and superficial applications in 83,778 patients.

"Declarations Ethics approval and consent to participateThe protocol of this retrospective observational study was approved by the Institutional Review Board of the First Affiliated Hospital of Sun Yat-Sen University. Since it was a retrospective study, informed consent of the patients could not be obtained, but all patients have signed informed consent before CEUS. Consent for publicationSince it was a retrospective study, informed consent of the patients could not be obtained, but all patients have signed informed consent before CEUS. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding Guangzhou Science and Technology Program No.202201011157, National Natural Science Foundation of China No.82102057, No.82071951, No.92059201, and Guangdong Basic and Applied Basic Research Foundation No.2020A1515111055 provided funding for the research. The funding body played a role in the collection and interpretation of data in the research."