Leishmania highjack host lipid body for its proliferation in macrophages by overexpressing host Rab18 and TRAPPC9 by downregulating miR-1914-3p expression.

Authors:
Sood C; Verma JK; Basak R; Kapoor A; Gupta S and 1 more

Journal:
PLoS Pathog

Publication Year: 2024

DOI:
10.1371/journal.ppat.1012024

PMCID:
PMC10898768

PMID:
38412149

Journal Information

Journal Title: PLoS Pathog

Detailed journal information not available.

Publication Details

Subject Category: Virology

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

Transparency Score
4/6
66.7% Transparent
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Evidence found in paper:

"the whole microarray data have been submitted in gene expression omnibus database (accession number gse89529) b sequence alignment of 3 / -utr of host rab18 and trappc9 containing 7-mer target site with the seed region of mir-1914-3p predicted by tagetscan tool."

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"The authors have declared that no competing interests exist."

Evidence found in paper:

"This work is supported by grants from Department of Biotechnology, Government of India [BT/PR42073/BRB/10/1979/2021] and J.C. Bose Fellowship (SR/S2/JCB-24/2009) to AM by Science and Engineering Research Board, Government of India. CS is supported by fellowship from J.C. Bose Fellowship to AM. JKV (13(9095-A)/2019-Pool), AK (09/086(1373)/2019-EMR-I) and SG (09/086(0085)/2020-EMR-I) are supported by fellowships from the Council of Scientific and Industrial Research, Government of India. RB (2018BLZ8469) is supported by fellowship from Indian Institute of Technology, New Delhi, India. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."

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Last Updated: Aug 05, 2025