The neutrophil-osteogenic cell axis promotes bone destruction in periodontitis.

"the referenced publicly available datasets were downloaded from the gene expression omnibus (geo) (scrna-seq data of human periodontal lesions; gse164241 the epigenomic datasets of osteogenic cell epigenomic datasets; gse51515 gse54782 and gsm733779) and encode project databases (dnase-seq data of human pdl fibroblasts; encdo247aaa).; the processed files of scrna-seq data for mouse periodontitis are deposited in the geo under accession gse254766."

"Competing interests The Department of Osteoimmunology is an endowment department supported with an unrestricted grant from AYUMI Pharmaceutical Corporation, ELECOM, JCR Pharmaceuticals, Kondo Cotton Spinning, MIKIHOUSE, MITSUI FUDOSAN, Meiji, Noevir, TAKENAKA, TENNENBUTSU IKAGAKU KENKYU ZAIDAN and Yakult."

"We thank S. Yin, K. Kusubata, A. Suematsu, K. Kubo, T. Tsubokawa, N. Takeda, and I. Komuro for thoughtful discussion and valuable technical assistance. This work was supported in part by the Japan Agency for Medical Research and Development (AMED) under grant number JP20ek0410073, JP23ek0410108, JP22ek0410100, AMED-CREST under grant number JP19gm1210008 and AMED-PRIME under grant number JP21gm6310029, the AMED Japan Initiative for World leading Vaccine Research and Development Centers (JP223fa627001); Japan Society for the Promotion of Science (JSPS): Scientific Research S (21H05046), Scientific Research B (21H03104, 22H03195, and 22H02844) and Challenging Research (20K21515 and 21K18254); and the JST FOREST Program (JPMJFR2261, JPMJFR205Z). Y.A. was supported by a JSPS Research Fellowship for Young Scientists (23KJ1949) and Japanese Society for Immunology (JSI) Kibou Scholarship for Doctoral Students in Immunology."