Revisiting multi-omics-based predictors of the plasma triglyceride response to an omega-3 fatty acid supplementation.

"Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest."

"The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was funded by the Canadian Institutes of Health Research (CIHR) Project Grant (201909PJT-427057-NUT-CFBA-40819)."

"Between 2009 and 2011, a total of 254 healthy subjects living in the Quebec City metropolitan area were recruited to take part in the FAS Study. To be eligible, subjects must have not taken any n-3 FA supplements 6 months prior to the intervention, be non-smokers and have no thyroid or metabolic disorders requiring pharmacological treatment. Participants must have a body mass index (BMI) between 25 and 40 kg/m2 and be aged between 18 and 50. A total of 210 people completed the intervention protocol. Two participants were excluded from further analyses due to missing values prior to supplementation. Of the remaining 208 participants, those whose plasma TG levels decreased after the n-3 FA supplementation (ΔTG levels < 0) were defined as responders, while non-responders were participants for whom the TG concentrations remained stable or increased after the n-3 FA supplementation (ΔTG levels ≥ 0), as previously described (). This study was approved by the ethics committees of Center de recherche du CHU de Québec and Université Laval and registered as NCT01343342 at ClinicalTrials.gov. All participants provided written informed consent prior to participation in accordance with the Declaration of Helsinki."