Effects of structurally distinct human HDAC6 and HDAC6/HDAC8 inhibitors against S. mansoni larval and adult worm stages.

"importantly this compound increases histone and tubulin acetylation in s mansoni parasites representing a candidate worthy of further consideration as starting point for the development of new generation anti- schistosoma chemotherapeutics s1 data (xlsx) s1 table a sasa predicted the total solvent accessible surface (range or recommended value for 95% of known drugs300-1000); b qplogp predicted octanol/water partition coefficient (range or recommended value for 95% of known drugs -2-6 5); c qplogs predicted aqueous solubility in mol/dm 3 (range or recommended value for 95% of known drugs -6 5-0 5); d qppcaco predicted apparent caco-2 cell permeability in nm/sec (range or recommended value for 95% of known drugs >500 great); e qppmdck predicted apparent mdck cell permeability in nm/sec (range or recommended value for 95% of known drugs >500 great); f qplogherg predicted ic 50 values for blockage of herg k + channels (range or recommended value for 95% of known drugs below -5); g %hoa predicted human oral absorption on 0 to 100% scale (range or recommended value for 95% of known drugs >80% high). xlsx) s1 table"

"The authors have declared that no competing interests exist."

"This work was supported by the Ministero dell’Università e della Ricerca (MUR), PRIN Project No. 20154JRJPP to G.C. and G.R. and by the CNR (National Research Council)-CNCCS (Collezione Nazionale di Composti Chimici e Centro di Screening) “Rare, Neglected and Poverty Related Diseases Schistodiscovery Project” (DSB.AD011.001.003 to G. R.) and by the Lazio Innova POR FESR Lazio 2014 to 2020 HDACiPLAT Project (grant number A0375-2020-36575 to G. R.) The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. RG received salary for postdoctoral fellowship from Lazio Innova grant."