Plasmodium falciparum contains functional SCF and CRL4 ubiquitin E3 ligases, and CRL4 is critical for cell division and membrane integrity.

"plos publication stage vor-update-to-uncorrected-proof publication update 2024-03-11 data availability the mass spectrometry proteomics data have been deposited to the proteomexchange consortium via the pride partner repository with the following freely accessible dataset identifiers and links pxd040195 (pfcullin-1; http://www ebi ac uk/pride/archive/projects/pxd040195 ) pxd040090 (pfrbx1; http://www ebi ac uk/pride/archive/projects/pxd040090 ) pxd040194 (pfskp1; http://www ebi ac uk/pride/archive/projects/pxd040194 ) pxd040268 (pfcullin-2; http://www ebi ac uk/pride/archive/projects/pxd040268 ) pxd040197 (lfq; http://www ebi ac uk/pride/archive/projects/pxd040197 ).; data availability the mass spectrometry proteomics data have been deposited to the proteomexchange consortium via the pride partner repository with the following freely accessible dataset identifiers and links pxd040195 (pfcullin-1; http://www ebi ac uk/pride/archive/projects/pxd040195 ) pxd040090 (pfrbx1; http://www ebi ac uk/pride/archive/projects/pxd040090 ) pxd040194 (pfskp1; http://www ebi ac uk/pride/archive/projects/pxd040194 ) pxd040268 (pfcullin-2; http://www ebi ac uk/pride/archive/projects/pxd040268 ) pxd040197 (lfq; http://www ebi ac uk/pride/archive/projects/pxd040197 )."

"The authors have declared that no competing interests exist."

"This study was supported by grants from the Department of Biotechnology, India (BT/PR11497/MED/29/854/2014) and Council of Scientific and Industrial Research, India (MLP0148) to PSS. ZR is the recipient of fellowship from the Department of Biotechnology, India. GSR is the recipient of fellowship from the Council of Scientific and Industrial Research, India. SMG is the recipient of fellowship from University Grants Commission, India. The salary of PP was supported with funds from the Council of Scientific and Industrial Research, India (MLP0148). The salary of DD was supported with funds from the Department of Biotechnology, India (BT/PR11497/MED/29/854/2014). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."