A study protocol to investigate if acipimox improves muscle function and sarcopenia: an open-label, uncontrolled, before-and-after experimental medicine feasibility study in community-dwelling older adults.

Authors:
McDonald C; Alderson C; Birkbeck MG; Brown L; Del Din S and 10 more

Journal:
BMJ Open

Publication Year: 2024

DOI:
10.1136/bmjopen-2023-076518

PMCID:
PMC10900389

PMID:
38417968

Journal Information

Full Title: BMJ Open

Abbreviation: BMJ Open

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Medicine

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

Transparency Score
5/6
83.3% Transparent
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Core Indicators
Evidence found in paper:

"the study team will then telephone the potential participant and those wishing to take part will then be invited to a screening visit 10 1136/bmjopen-2023-076518 supp1 supplementary data 10 1136/bmjopen-2023-076518 supp2 supplementary data written informed consent will be obtained at the screening visit which may take place at home in clinic or in a research facility."

Code Sharing
Evidence found in paper:

"Competing interests: S. Del Din reports consultancy activity with Hoffmann-La Roche Ltd. outside of this study."

Evidence found in paper:

"Funding: This work was funded by the UKRI Medical Research Council Confidence in Concept funding scheme (grant number MC_PC_19047)."

Evidence found in paper:

"Trial registration number The ISRCTN trial database (ISRCTN87404878)."

Open Access
Paper is freely available to read
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Tool: rtransparent

OST Version: N/A

Last Updated: Aug 05, 2025