Mutual interaction of neurons and astrocytes derived from iPSCs with APP V717L mutation developed the astrocytic phenotypes of Alzheimer's disease.

"Declarations Ethics approval and consent to participateThe study was conducted per the Declaration of Helsinki, approved by the Ethics Committee for Human Research of the Keio University School of Medicine (#20080016). Consent for publicationNot applicable. Competing interestsH.O. is a founder scientist and a Scientific Advisory Board Member for SanBio Co., Ltd., and K Pharma Inc. The remaining authors declare no conflicts of interest. H.O. is the Editor-in-Chief of Inflammation and Regeneration. Competing interests H.O. is a founder scientist and a Scientific Advisory Board Member for SanBio Co., Ltd., and K Pharma Inc. The remaining authors declare no conflicts of interest. H.O. is the Editor-in-Chief of Inflammation and Regeneration."

"Funding This research was funded by the Grants-in-Aid for Scientific Research (KAKENHI, #21J21244 to S.S. (Sopak Supakul), #22J11065 to R.M., #21H02450, #23K18116, and #21K06376 to S.M.), the Keio Global Research Institute from Keio University (to S.M. and H.O.), the Japan Agency for Medical Research and Development (AMED) [The Acceleration Program for Intractable Disease Research Utilizing Disease-specific iPS Cells to S.M. and H.O. (JP21bm0804003)] [Cyclic Innovation for Clinical Empowerment to S.M. and H.O. (JP17pc0101006)], [Research and Development Grants for Dementia to S.M. (22dk0207060)], the Keio University Doctorate Student Grant-in-Aid Program from Ushioda Memorial Fund 2021 (to S.S. (Sopak Supakul)), and the research grant from Keio Medical Association (the fiscal year 2022) (to S.S. (Sopak Supakul))."