Prevention of post-operative delirium using an overnight infusion of dexmedetomidine in patients undergoing cardiac surgery: a pragmatic, randomized, double-blind, placebo-controlled trial.

"Declarations Ethics approval and consent to participateThe study was approved for all participating centres by the French central ethics committee (Comité de protection des personnes Ile de France VI) with the registration number 2018-000850-22. The trial was conducted in accordance with the declaration of Helsinki. Written informed consent was obtained from all included patients. Consent for publicationA written inform consent for publication was obtained. Competing interestThe authors declare no competing interest for this manuscript. Competing interest The authors declare no competing interest for this manuscript."

"Funding The EXACTUM study was funded by the PHRC inter-regional 2017 (funding n°: API17/B/053). Baxter provided the study drug. Brest university hospital sponsored the study. Funders of the study had no role in the study design, data collection, data analysis, data interpretation or writing the manuscript."

"Trial registration This trial was registered on ClinicalTrials.gov (number: NCT03477344; date: 26th March 2018)."