Ongoing evolution of the Mycobacterium tuberculosis lactate dehydrogenase reveals the pleiotropic effects of bacterial adaption to host pressure.

"plos publication stage vor-update-to-uncorrected-proof publication update 2024-03-12 data availability all data are available in the main text or supplementary materials ; sequencing data are deposited in the sequence read archive database (prjna1026166).; data availability all data are available in the main text or supplementary materials ; sequencing data are deposited in the sequence read archive database (prjna1026166). blue indicates labeled carbon ions grey represents total carbon ions (pdf) s1 table (xlsx) s2 table (xlsx) s3 table (xlsx) s1 data (xlsx) 10 1371/journal ppat 1012050 r001 decision letter 0 bessen debra e section editor boshoff helena ingrid academic editor (c) 2024 bessen boshoff 2024 bessen boshoff https://creativecommons org/licenses/by/4 0/ this is an open access article distributed under the terms of the creative commons attribution license which permits unrestricted use distribution and reproduction in any medium provided the original author and source are credited. s1 table (xlsx data availability all data are available in the main text or supplementary materials ; sequencing data are deposited in the sequence read archive database (prjna1026166"

"The authors have declared that no competing interests exist."

"National Institutes of Allergy and Infectious Diseases (https://www.niaid.nih.gov): P01 AI132130 (S.S., S.M.F.); P01 AI143575 (X.W., S.M.F.); U19 AI142793 (Q.L., S.M.F.); 5T32AI132120-03 (S.S); 5T32AI132120-04 (S.S.); 5T32AI049928-17 (S.S.); Harvard Graduate Program in Tropical Infectious Diseases Training Grant T32AI049928 (A.M.F.) National Institute of Child Health and Human Development (https://www.nichd.nih.gov): 5T32HD040128-19 (S.S.) National Institutes of Health (https://www.nih.gov):R00DK117066 (S.H.) The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."