Denervation alters the secretome of myofibers and thereby affects muscle stem cell lineage progression and functionality.

"data availability the rna sequencing data discussed in this publication have been deposited in ncbi's gene expression omnibus59 and are accessible through geo series accession numbers gse217928 and gse217929.; the mass spectrometry proteomics data have been deposited to the proteomexchange consortium via the pride 60 - 62 partner repository with the dataset identifier pxd036993. data availability the rna sequencing data discussed in this publication have been deposited in ncbi's gene expression omnibus59 and are accessible through geo series accession numbers gse217928"

"Competing interests The authors declare no competing interests. The authors of this manuscript certify that they comply with the Ethical guidelines for authorship and publishing in the Journal of Cachexia, Sarcopenia and Muscle63. The manuscript does not contain clinical studies or patient data."

"Funding Open Access funding enabled and organized by Projekt DEAL."