Tight junction protein cingulin variant is associated with cancer susceptibility by overexpressed IQGAP1 and Rac1-dependent epithelial-mesenchymal transition.

"Declarations Ethics approval and consent to participateThese studies were approved by the institutional review board (IRB) of National Cheng Kung University Hospital and conducted in accordance with the Declaration of Helsinki (IRB number: A-ER-104-153 and A-ER-103-395). Written informed consents were provided by all patients. The animal experiments were approved by the Institutional Animal Care and Use Committee (IACUC) of National Cheng Kung University (approval no. 110221, 2021/04/21) and followed the ethical guidelines. Consent for publicationAll authors have agreed to publish this manuscript. Competing interestsThe authors declare that they have no conflict of interest. Competing interests The authors declare that they have no conflict of interest."

"Funding This study was supported by the Ministry of Science and Technology (MOST 111–2634-F-006-002), and the Ministry of Health and Welfare (MOHW 111-TDU-B-221-114005, MOHW113-TDU-B-221-134005)."