Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NFκB-mediated barrier protection.

"raw sequencing data is submitted under project accession number gse237496 to the geo gene accession omnibus.; raw sequencing data is submitted under project accession number gse237496 to the geo gene accession omnibus.; raw files are accessible under the gene expression omnibus accession number gse237496 ( https://www ncbi nlm nih gov/geo/query/acc cgi? data availability programming code and data necessary to generate plots shown in this manuscript were deposited at github: https://github com/schsascha/cal_translocation .; data availability programming code and data necessary to generate plots shown in this manuscript were deposited at github: https://github com/schsascha/cal_translocation .; programming code and data necessary to generate plots shown in this manuscript were deposited at github: https://github com/schsascha/cal_translocation . xlsx) s3 table all data all data used to generate the graphs is provided as source data ( s3 table data availability programming code and data necessary to generate plots shown in this manuscript were deposited at github: https://github com/schsascha/cal_translocation . raw sequencing data is submitted under project accession number gse237496"

"data availability programming code and data necessary to generate plots shown in this manuscript were deposited at github: https://github com/schsascha/cal_translocation .; data availability programming code and data necessary to generate plots shown in this manuscript were deposited at github: https://github com/schsascha/cal_translocation .; programming code and data necessary to generate plots shown in this manuscript were deposited at github: https://github com/schsascha/cal_translocation ."

"The authors have declared that no competing interests exist."

"JLS, AL, LK, BH, SaS, PG, and GP were supported by the German Research Foundation (Deutsche Forschungsgemeinschaft – DFG) within the Collaborative Research Centre (CRC)/Transregio (TRR) 124 “FungiNet” projects C1 and INF (DFG project number 210879364). TBS was supported by the DFG under Germany’s Excellence Strategy – EXC 2051 – Project ID 390713860. VT was supported by the German Federal Ministry of Education and Research (BMBF) within the funding program Photonics Research Germany, Leibniz Center for Photonics in Infection Research (LPI) (subproject LPI-BT2; contract number 13N15705). GP was also supported by the BMBF within the funding project PerMiCCion (project ID: 01KD2101A). JRN was supported by grants from the Wellcome Trust (214229_Z_18_Z) and National Institutes of Health (DE022550). DW was supported by a Wellcome Trust Senior Research Fellowship (214317/Z/18/Z), the MRC Centre for Medical Mycology at the University of Exeter (MR/N006364/2 and MR/V033417/1), and the NIHR Exeter Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."