Single-cell RNA sequencing reveals peripheral blood leukocyte responses to spinal cord injury in mice with humanised immune systems.

"availability of data and materials raw and processed sequencing data generated as part of this study have been deposited to the gene expression omnibus repository ( https://www ncbi nlm nih gov/geo/ ) and are available publicly under the accession number gse236293."

"code to reproduce scrnaseq figures presented in this paper is available at our dedicated github site for mapping cellular ecosystems in spinal cord injury (precision): https://github com/biomedicalmachinelearning/precision ."

"Declarations Ethics approval and consent to participateHuman umbilical cord blood was obtained from the Queensland Cord Blood Bank at the Mater, with written informed consent and approval from the Mater Misericordiae Human Ethics Committee (1586M). All animal experiments/procedures were approved by The University of Queensland Animal Ethics Committee and conducted in accordance with the Australian Code for the Care and Use of Animals for Scientific Purposes. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This work was made possible by the Wings for Life Spinal Cord Research Foundation (Project Grants to MJR and QHN, and Fellowship to LFG), a UQ Faculty of Medicine – Metro South Health Collaboration Grant (to MJR and JW), SpinalCure Australia (MJR) and the NHMRC (Project Grants 1060538 and 1163835). ERG and WJ were supported by Research Training Program Scholarships (Australian Government), and The University of Queensland’s Joan Hume Scholarship (to ERG). KR was supported by the Mater Foundation."