Riboflavin-LSD1 axis participates in the in vivo tumor-associated macrophage morphology in human colorectal liver metastases.

"Declarations Competing interestsThe authors declare that they have no competing interests. Ethical approval and consent to participateThe study protocol was submitted to the international clinical trial registry (ClinicalTrials.gov Registration Number NCT03888638) and approved by the IRCCS Humanitas Research Hospital Ethical Committee (Registration Number 282/19). Consent for publicationAll authors have read the manuscript and agree to publish. Competing interests The authors declare that they have no competing interests."

"This study was supported by the Italian Ministry of Health Grant Number RF-2018-12367150."

"The study included fourteen patients who underwent surgery at the IRCCS Humanitas Research Hospital between 2020 and 2022 for CLM (Table ). The study protocol, submitted to the international clinical trial registry (ClinicalTrials.gov registration number NCT03888638), was designed to identify macrophage-related morphological features associated with distinct clinical outcomes. Written informed consent was obtained from each patient included in the study. The study protocol was in accordance with the ethical guidelines established in the 1975 Declaration of Helsinki and compliant with the procedures of the local ethical committee of the IRCCS Humanitas Research Hospital (registration number 282/19). Declarations: Competing interestsThe authors declare that they have no competing interests.: Ethical approval and consent to participateThe study protocol was submitted to the international clinical trial registry (ClinicalTrials.gov Registration Number NCT03888638) and approved by the IRCCS Humanitas Research Hospital Ethical Committee (Registration Number 282/19).: Consent for publicationAll authors have read the manuscript and agree to publish. Ethical approval and consent to participate: The study protocol was submitted to the international clinical trial registry (ClinicalTrials.gov Registration Number NCT03888638) and approved by the IRCCS Humanitas Research Hospital Ethical Committee (Registration Number 282/19)."