Lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug-resistant <i>Candida auris</i>.

"data availability all rna-seq data are available in the ncbi database (gene expression omnibus [geo]) under the accession number gse244094. data availability all rna-seq data are available in the ncbi database (gene expression omnibus [geo]) under the accession number gse244094"

"Disclosure statement No potential conflict of interest was reported by the author(s)."

"We acknowledge the CDC and BEI Resources, which provided the fungal isolates used in this study. The NIH Clinical Collections 1 & 2 were provided by the National Institutes of Health (NIH). S. cerevisiae AD1-9 strain was kindly provided by M. Ghislain, UCL, Belgium. We also acknowledge the support of the Collaborative Core for Cancer Bioinformatics from the Purdue University Institute for Cancer Research (PU-ICR), NIH grants R01AI141439, P30 CA023168 and the Walther Cancer Foundation. We also thank Dr. Hassan Eldesouky for his help with the library screening."