The proteome of the blood-brain barrier in rat and mouse: highly specific identification of proteins on the luminal surface of brain microvessels by in vivo glycocapture.

Authors:
Tremblay TL; Alata W; Slinn J; Baumann E; Delaney CE and 4 more

Journal:
Fluids Barriers CNS

Publication Year: 2024

DOI:
10.1186/s12987-024-00523-x

PMCID:
PMC10910681

PMID:
38433215

Journal Information

Journal Title: Fluids Barriers CNS

Detailed journal information not available.

Publication Details

Subject Category: Neurosciences

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

Transparency Score
5/6
83.3% Transparent
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Evidence found in paper:

"supplementary data contains detailed protein identification lists for each individual experiment (additional file 1 : data s1) and the peptide-spectrum match details (additional file 2 : data s2).; additional file 1: data s1.; additional file 2: data s2."

Evidence found in paper:

"the tsv output files from msfragger which included decoy database hits were subsequently filtered using a python script to only keep peptide-spectrum-match (psm) rows that contained at least one consensus n-glycosylation sequence (n-x(!"

Evidence found in paper:

"Declarations Ethics approval and consent to participateAll animal studies were performed in accordance with the Canadian Council on Animal Care and were approved by the Animal Care Committee of the National Research Council Canada. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

Evidence found in paper:

"Funding This work was supported by the Beyond Brain Barriers and Multifunctional Antibody Therapeutics Programs at the National Research Council of Canada."

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Open Access
Paper is freely available to read
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Last Updated: Aug 05, 2025