B cell repertoire sequencing of HIV-1 pediatric elite-neutralizers identifies multiple broadly neutralizing antibody clonotypes.

Authors:
Kumar S; Bajpai P; Joyce C; Kabra SK; Lodha R and 3 more

Journal:
Front Immunol

Publication Year: 2024

DOI:
10.3389/fimmu.2024.1272493

PMCID:
PMC10905035

PMID:
38433846

Journal Information

Full Title: Front Immunol

Abbreviation: Front Immunol

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Allergy and Immunology

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

Transparency Score
5/6
83.3% Transparent
Transparency Indicators
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Core Indicators
Evidence found in paper:

"raw sequence data that support the findings in this study are available at the ncbi sequencing read archive ( www ncbi nlm nih gov/sra ) under bioprojectnumber: prjna999025. processed datasets are available at https://github com/prashantbajpai/hiv_bcr_analysis .; raw data used for generating the figures are available at the github page or in the supplementary files ."

Evidence found in paper:

"processed datasets are available at https://github com/prashantbajpai/hiv_bcr_analysis .; raw data used for generating the figures are available at the github page or in the supplementary files . raw data used for generating the figures are available at the github page or in the supplementary files ."

Evidence found in paper:

"Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision."

Evidence found in paper:

"The author(s) declare financial support was received for the research, authorship, and/or publication of this article. We are thankful to the SERB, India (CRG/2021/003984), and Department of Biotechnology (DBT) (BT/PR 24520/MED/29/1222/2017) for the funding provided to KL. This study is supported in part by ViiV Healthcare and the HIV Research Trust Scholarship 2019 awarded to SK as part of his Graduate (Ph.D.) work training and gaining expertise in Next Generation Sequencing based technologies to sequence single B cell and bulk B cell repertoire sequencing. We are thankful to the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), for the fundings provided to BB (P01 AI177683, P30 AI036214, and R35 GM133682), and the funding provided to DRB (UM1 AI144462). SK is supported by the DBT/Wellcome Trust India Alliance Early Career Fellowship (IA/E/18/1/504307). The funders had no role in the decision to publish or the preparation of the manuscript."

Protocol Registration
Open Access
Paper is freely available to read
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Tool: rtransparent

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Last Updated: Aug 05, 2025