Schwann cells acquire a repair phenotype after assembling into spheroids and show enhanced in vivo therapeutic potential for promoting peripheral nerve repair.

"CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interests."

"This work was financially supported by the National Science and Technology Council in Taiwan (111‐2628‐B‐007‐004, 112‐2314‐B‐007‐003, 111‐2314‐B‐182‐064 [NMRPD1M1231], and 112‐2628‐B‐182‐005 [NMRPD1N1071]), by National Health Research Institutes (NHRI‐EX112‐11131EI), by CGMH‐NTHU Joint Research Program (110Q2509E1 and 112F7MCPE1), by National Tsing Hua University (112Q2714E1, 112QI015E1 and 112F7MDCE1), and by Chang Gung Memorial Hospital (CMRPG3N0681, CMRPG3N0682, CORPG3N0111, and CORPG3N0112). The authors thank JelloX Biotech Inc. (Hsinchu, Taiwan) for technical support in tissue clearing and imaging. The authors also thank the technical assistant from the Biomedical Science and Engineering Center, National Tsing Hua University (Hsinchu, Taiwan) for help with confocal laser scanning microscopy."