Transplantation of the LRP1^high subpopulation of human umbilical cord-derived mesenchymal stem cells improves ovarian function in mice with premature ovarian failure and aged mice.

"availability of data and materials the sequencing data sets have been deposited in ncbi's gene expression omnibus (geo) and are accessible through the geo accession number gse239500 and gse240185. availability of data and materials the sequencing data sets have been deposited in ncbi's gene expression omnibus (geo) and are accessible through the geo accession number gse239500"

"Declarations Ethics approval and consent to participateInformed consents were obtained from all participants, and the study protocol in this study was approved by the Medical Ethics Committee of Shanghai First Maternity and Infant Hospital in Tongji University on 17th July 2019 (Title: “Clinical study of human umbilical cord mesenchymal stem cells in treatment of premature ovarian failure and endometrial repair”, Ethics number: KS1956). Animal experiments in this study were approved by Animal Ethics Committee of Tongji University on 20th November 2022 (Title: “Transplantation of LRP1high UC-MSCs subsets improves ovarian function and improves POF treatment”, Ethics number: TJAB03223124). All experiments were conducted in compliance with the ARRIVE guidelines. Consent for publicationNot applicable. Competing interestsThe authors have declared that no competing interests exist. Competing interests The authors have declared that no competing interests exist."

"Funding This work was supported by grants from the National Natural Science Foundation of China (Grant No. 32270840), Natural Science Foundation of Shanghai (Grant No. 21ZR1450900) and the Shanghai Science and Technology Planning Project (grant no. 21Y11907000)."