AcumenTM hypotension prediction index guidance for prevention and treatment of hypotension in noncardiac surgery: a prospective, single-arm, multicenter trial.

"Declarations Ethics approval and consent to participateThe trial was approved by a central Institutional Review Board (IRB; Western IRB approval #1-1131056-1) and 8 local IRBs. Written informed consent was obtained from each subject in the prospective trial, but not from subjects who were retrospectively included in the comparison groups. Consent for publicationNot applicable. Competing interestsXB, HC, CC, GM, LM, DP, MP, SR, MT, GW, MW declare that they have no competing interests.KD received grants or contracts in the past 36 months from Anesthesia Patient Safety Foundation regarding NORA, and lecture honoraria from Northwest Anesthesia Seminars; she serves as Committee Chair for the ASA Committee on Practice Parameters.DD received grants or contracts in the past 36 months from NIH – NIA and Masimo Inc, and consulting fees from Masimo Inc.SK received grants or contracts in the past 36 months from Edwards Lifesciences, PCORI, and Hemosonics; honoraria from ROTEM for lecture; and reimbursement from Edwards Lifesciences for travel to a research meeting.KM received grants or contracts and consulting fees in the past 36 months from Edwards Lifesciences and Phillips Healthcare.NS received grants or contracts in the past 36 months from Edwards Lifesciences, Blue Cross Blue Shield Michigan, National Institute of Aging, American Heart Association. Competing interests XB, HC, CC, GM, LM, DP, MP, SR, MT, GW, MW declare that they have no competing interests. KD received grants or contracts in the past 36 months from Anesthesia Patient Safety Foundation regarding NORA, and lecture honoraria from Northwest Anesthesia Seminars; she serves as Committee Chair for the ASA Committee on Practice Parameters. DD received grants or contracts in the past 36 months from NIH – NIA and Masimo Inc, and consulting fees from Masimo Inc. SK received grants or contracts in the past 36 months from Edwards Lifesciences, PCORI, and Hemosonics; honoraria from ROTEM for lecture; and reimbursement from Edwards Lifesciences for travel to a research meeting. KM received grants or contracts and consulting fees in the past 36 months from Edwards Lifesciences and Phillips Healthcare. NS received grants or contracts in the past 36 months from Edwards Lifesciences, Blue Cross Blue Shield Michigan, National Institute of Aging, American Heart Association."

"Funding The study sponsor is Edwards Lifesciences LLC, One Edwards Way, Irvine, CA 92614."

"Trial registration Clinical trial number: NCT03805217. Registry URL: https://clinicaltrials.gov/ct2/show/NCT03805217. Principal investigator: Xiaodong Bao, MD, PhD. Date of registration: January 15, 2019."