The transmembrane channel-like 6 (TMC6) in primary sensory neurons involving thermal sensation via modulating M channels.

"Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest."

"The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (U21A20359) grants and Science Fund for Creative Research Groups of Natural Science Foundation of Hebei Province (no. H2020206474) to XD; the National Natural Science Foundation of China (81871075, 82071533) grants to HZ; the National Natural Science Foundation of Hebei Province (no. H2022206174) to WZ; Young Top-notch Talent Project of Hebei Provincial Education Department (BJK2024005) to WZ; the Natural Science Foundation of Hebei Province (H2023206361) to HH; the Youth Fund Project of Hebei Provincial Education Department (QN2024011) to HH."