Development and proof-of-concept demonstration of a clinical metagenomics method for the rapid detection of bloodstream infection.

"availability of data and materials all the sequencing data supporting the conclusions of this article are available at the european nucleotide archive (ena) repository under accession prjjeb64522 ( https://www ebi ac uk/ena/browser/view/prjeb64522 ). availability of data and materials all the sequencing data supporting the conclusions of this article are available at the european nucleotide archive (ena) repository under accession prjjeb64522"

"Declarations Ethics approval and consent to participateNot applicable. Consent for publication:Not applicable. Competing interestsLMS has received financial support through the DART iCASE grant by Momentum Bioscience Ltd. AA, GLK and JOG are employed by Oxford Nanopore Technologies plc. and hold shares and share options in the company. EM, DSL and WM are employed by Momentum Bioscience Ltd. TLV, CH, NE and MWG have no competing interests. Competing interests LMS has received financial support through the DART iCASE grant by Momentum Bioscience Ltd. AA, GLK and JOG are employed by Oxford Nanopore Technologies plc. and hold shares and share options in the company. EM, DSL and WM are employed by Momentum Bioscience Ltd. TLV, CH, NE and MWG have no competing interests."

"Funding LMS is funded by the MRC Doctoral Antimicrobial Research Training (DART) Industrial CASE Programme Project grant number MR/R015937/1. TLV was supported by the Quadram Institute Bioscience BBSRC funded Core Capability Grant (project number BB/CCG1860/1). CH is funded by the UK Ministry of Defence. This research was funded by the BBSRC Institute Strategic Programme Microbes in the Food Chain BB/R012504/1 and its constituent project BBS/E/F/000PR10352 (Theme 4, Research Infrastructure), the BBSRC Institute Strategic Programme Microbes and Food Safety BB/X011011/1 and its constituent project BBS/E/F/000PR13636 (Theme 3, Flexible capabilities to reduce food safety threats and respond to national needs) and Innovate UK project TS/S00887X/1."