Mesenchymal stem/stromal cells from human pluripotent stem cell-derived brain organoid enhance the ex vivo expansion and maintenance of hematopoietic stem/progenitor cells.

"availability of data and materials the data discussed in this publication have been deposited in ncbi's gene expression omnibus and are accessible through geo series accession number gse220781. availability of data and materials the data discussed in this publication have been deposited in ncbi's gene expression omnibus and are accessible through geo series accession number gse220781"

"Declarations Ethics approval and consent to participateThis research does not contain clinical experiments. All the experiments are approved under the project of “Identification the role and mechanism of mesenchymal stem cells isolated from human brain-specific organoids in human hematopoiesis” by the institutional ethics review committee of Institute of Blood Transfusion, Chinese Academy of Medical Sciences, China. The approval number is 202030. The use of the human umbilical cord tissue from a healthy donor. Written informed consent was obtained from the pregnant women before labor. The approval date for these animal experiments and the use of human umbilical cord-derived MSCs is 2020-09-16. Our manuscript is reported following the ARRIVE guidelines. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This work was supported by the National Natural Science Foundation of China (82170121, awarded to F.M.; 82000119, awarded to Y.Z.), the CAMS Initiatives for Innovative Medicine (2021-I2M-1-060, awarded to J.X.L) and the Sichuan Science and Technology Program (2023NSFSC1705, awarded to Y.Z.)."