Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation.

"Declarations Ethics aspproval and consent to participateThe generation and use of the iPSCs in this study were approved by the Ethics Committees of RIKEN BioResource Research Center, and Department of Medicine and Graduate School of Medicine, Kyoto University. All experiments in this study were performed in accordance with the approved guidelines. Formal informed consent was obtained from all subjects. The parental fibroblasts of PD#2-1 and PD# 2-2 were obtained from the NIGMS Human Genetic Cell Repository at the Coriell Institute for Medical Research (Catalog ID: ND40996). Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This research was funded in part by AMED under Grant Number JP23bm1323001, JP22bm0804034, JP23bm1423014, JP23bm1423012 to HI, KAKENHI under Grant Number 21H02807 to HI, 20K07968, 23K06827 to KI, Uehara Memorial Foundation to HI, and the Canon Foundation to HI."