Population pharmacokinetics, enzyme occupancy, and pharmacodynamic modeling of soticlestat in patients with developmental and epileptic encephalopathies.

Authors:
Yin W; Facius A; Asgharnejad M; Lahu G; Vakilynejad M.

Journal:
Clin Transl Sci

Publication Year: 2024

DOI:
10.1111/cts.13722

PMCID:
PMC10915720

PMID:
38445548

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Journal Information

Journal Title: Clin Transl Sci

Detailed journal information not available.

Publication Details

Subject Category: Medicine, Research & Experimental

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

Transparency Score

4/6

66.7% Transparent

Transparency Indicators

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Core Indicators

Data Sharing

Evidence found in paper:

"data s1."

Code Sharing

COI Disclosure

Evidence found in paper:

"CONFLICT OF INTEREST STATEMENT W. Yin and M. Asgharnejad are employees of Takeda Pharmaceutical Company Ltd and own stock or stock options. M. Vakilynejad is a former employee of Takeda Pharmaceutical Company Ltd. A. Facius and G. Lahu are former employees of Takeda and received payment for acting as consultants for Takeda at the time of data analysis."

Funding Disclosure

Evidence found in paper:

"FUNDING INFORMATION All studies included in this manuscript were funded by the sponsor, Takeda Pharmaceutical Company Ltd."

Protocol Registration

Open Access

Paper is freely available to read

Additional Indicators

Replication

Novelty Statement

Assessment Info

Tool: rtransparent

OST Version: N/A

Last Updated: Aug 05, 2025