Glial reactivity in a mouse model of beta-amyloid deposition assessed by PET imaging of P2X7 receptor and TSPO using [¹¹C]SMW139 and [¹⁸F]F-DPA.

"a description of the analytical workflow and image processing source code for the quantification of p2x7 receptor staining are available in additional file 1 ."

"Declarations Ethics approval and consent to participateThe Animal Experiment Board of the Province of Southern Finland (ESAVI/4660/04.10.07/2016) granted ethical approval of this study. Animal studies were performed in accordance with the European Ethics Committee (decree 86/609/CEE), and adhered to the ARRIVE guidelines, except randomization or blinding. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This work was funded by the Drug Research Doctoral Program at the University of Turku, the Swedish Cultural Foundation in Finland (OS and MHS), Finnish governmental research funding (Nos. 13250 (MHS) and 11133 (OS)), and the Academy of Finland (nos. 310962 (JOR) and 334310 (OS))."