Circulating N-lactoyl-amino acids and N-formyl-methionine reflect mitochondrial dysfunction and predict mortality in septic shock.

"Declarations Competing interestsVKM is a member of the scientific advisory board of 5AM Ventures. RSR began full-time employment with Vertex Pharmaceuticals in September 2023, after the initial submission of this work. Vertex Pharmaceuticals had no role in this study or its publication. Ethical approvalAll subjects (or legal surrogates) provided informed consent to participate in this study, which was approved by the Mass General Brigham IRB (Protocol 2017P002436). Competing interests VKM is a member of the scientific advisory board of 5AM Ventures. RSR began full-time employment with Vertex Pharmaceuticals in September 2023, after the initial submission of this work. Vertex Pharmaceuticals had no role in this study or its publication."

"Funding Funding for this project was provided by the Massachusetts General Hospital Department of Molecular Biology Mootha Lab Sundry Fund and the Marriott Family Foundation. RSR received salary support from the Parker B. Francis Family Foundation. VKM is an investigator of the Howard Hughes Medical Institute."