Reducing and controlling metabolic active tumor volume prior to CAR T-cell infusion can improve survival outcomes in patients with large B-cell lymphoma.

"code availability r codes are available from the corresponding author on reasonable request."

"Competing interests The Department of Radiation Oncology has research collaborations with Elekta, IBA, RaySearch, Siemens, Mirada, Bergoz Instrumentation and Medical Data Works, Genentech outside the submitted work. TvM received research grants from Genentech, Celgene/BMS; personal fees from Kite/Gilead and Janssen (advisory boards); and honoraria from Kite/Gilead and Celgene/BMS (speaker fees) outside the submitted work. LVvD received funding and salary support unrelated to this project from NWO ZonMw via the VENI (NWO-09150162010173) Individual career development grant and KWF Dutch Cancer Society Young Investigator Grant (KWF-13529). The other authors declare no conflict of interest."

"Competing interests: The Department of Radiation Oncology has research collaborations with Elekta, IBA, RaySearch, Siemens, Mirada, Bergoz Instrumentation and Medical Data Works, Genentech outside the submitted work. TvM received research grants from Genentech, Celgene/BMS; personal fees from Kite/Gilead and Janssen (advisory boards); and honoraria from Kite/Gilead and Celgene/BMS (speaker fees) outside the submitted work. LVvD received funding and salary support unrelated to this project from NWO ZonMw via the VENI (NWO-09150162010173) Individual career development grant and KWF Dutch Cancer Society Young Investigator Grant (KWF-13529). The other authors declare no conflict of interest."