The FBXW7-binding sites on FAM83D are potential targets for cancer therapy.

"Declarations Ethical approval5-week-old female BALB/c nude mice were purchased from Vital River Laboratory Animal Technology Co. (Beijing, China). The animals were bred in specific-pathogen-free conditions with a 12-h light–dark cycle. The experiments were approved by the ethics committee of the School of Basic Medical Sciences, Shandong University and were performed in guidance with animal experiments in the Laboratory Animal Center of Shandong University. 40 human breast cancer tissues along with their adjacent noncancerous tissues were obtained from the tumor tissue bank from the Shandong Provincial Hospital (Shandong, China). Informed consent was obtained from the patients for this study and the study was approved by the ethics committee of the School of Basic Medical Sciences, Shandong University. Conflict of interestThe authors declare that they have no competing interests. Conflict of interest The authors declare that they have no competing interests."

"Funding This work was supported by National Natural Science Foundation of China (32,371,363, 81,470,127 to P.-J.Z.), DOD BCRP (BC190820 to J.-H.M), and Natural Science Foundation of Shandong Province (ZR202211150041 to P.-J.Z.)."