Disease activity trajectories from childhood to adulthood in the population-based Nordic juvenile idiopathic arthritis cohort.

"the unstable results observed when using more than four groups led us to proceed with four groups10 1136/rmdopen-2023-003759 supp3 supplementary data 10 1136/rmdopen-2023-003759 supp1 supplementary data following the approach of shoop-worrall et al we modelled the active joint count using a zero-inflated poisson distribution and phga and paga using normal distributions.; we smoothened the resulting curves using a low-pass filter to obtain better visualisations of the results10 1136/rmdopen-2023-003759 supp2 supplementary data 10 1136/rmdopen-2023-003759 supp4 supplementary data 10 1136/rmdopen-2023-003759 supp5 supplementary data we constructed a heat-map plot by hierarchical clustering to explore factors associated with the paga.; the proportion of active disease according to the acr criteria and a cjadas10>1 was slightly higher when excluding these patients compared with the four groups when all the patients were included ( table 3 ) 10 1136/rmdopen-2023-003759 supp6 supplementary data 10 1136/rmdopen-2023-003759 supp7 supplementary data table 4 cjadas10 and components at the three major visits for each trajectory group in the nordic juvenile idiopathic arthritis cohort n baseline n 8-year follow-up n 18-year follow-up p value* group 1 (mida-id) cjadas10 70 1 7 (0-3 9) 101 0 (0-0 1) 147 0 (0-0 5) <0 0001 0 40 active joint count 168 0 (0-1 0) 168 0 (0-0) 167 0 (0-0) <0 0001 0 03 paga 84 0 5 (0-1 5) 123 0 (0-0) 151 0 (0-0 5) <0 0001 0 01 phga 73 0 5 (0-1 0) 103 0 (0-0) 163 0 (0-0) <0 0001 0 45 group 2 (mida-mda) cjadas10 55 2 2 (1 5-4 5) 78 1 5 (0-3 7) 94 4 0 (1 5-8 5) 0 20 0 008 active joint count 104 0 (0-1 0) 101 0 (0-1 0) 104 0 (0-1 0) 0 36 0 50 paga 65 0 5 (0-1 5) 83 0 2 (0-1 2) 95 2 0 (0 5-4 5) 0 28 <0 0001 phga 57 0 9 (0 3-1 2) 81 0 5 (0-1 5) 101 1 0 (0-2 0) 0 29 <0 0001 group 3 (hda-mida) cjadas10 71 8 4 (5 0-12 7) 85 1 5 (0 2-4 0) 113 1 0 (0-3 0) <0 0001 0 33 active joint count 119 3 0 (2 0-5 0) 115 0 (0-1) 119 0 (0-0) <0 0001 0 0004 paga 76 2 2 (1 0-4 3) 89 0 4 (0-1 9) 115 0 5 (0-2 0) <0 0001 <0 0001 phga 72 2 4 (1 0-4 2) 86 0 3 (0-1 3) 116 0 (0-0 5) <0 0001 0 58 group 4 (hda-hda) cjadas10 26 13 8 (6 6-19 0) 27 7 8 (2 6-15 5) 35 10 0 (6 5-14 0) 0 08 0 46 active joint count 36 4 0 (2 5-10 0) 36 2 5 (0-6 0) 36 2 0 (0-3 5) 0 01 0 38 paga 26 2 8 (1 0-6 2) 28 1 9 (0 5-5 1) 35 4 0 (2 0-7 5) 0 99 <0 0001 phga 27 4 4 (2 0-5 1) 29 2 3 (0 8-5 0) 36 3 0 (1 0-4 5) 0 39 <0 0001 disease activity trajectory groups from baseline to 18-year follow-up."

"Competing interests: None declared."

"Funding: The work was supported by postdoctoral grants from the Helse Nord Research Program."