Integrated analysis of transcriptome and genome variations in pediatric T cell acute lymphoblastic leukemia: data from north Indian tertiary care center.

"Declarations Ethics approval and consent to participateThe study was approved by Institutional Ethics Committee of Postgraduate Institute of Medical Education & Research, Chandigarh. Informed consent was taken from all the participants or parents. Consent for publicationNot Applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding The study is funded by Institutional Intramural Research Grant (PGIMER, Chandigarh, India)."

"Newly diagnosed pediatric T-ALL cases (age ≤12 years) confirmed on morphology and immunophenotype (flow cytometry) were enrolled for the study. Cases were classified immunophenotypically by flow cytometry into immature (pro T- and pre T-), cortical and mature T-ALL based on the EGIL criteria []. ETP-ALL was recognized based on the previously defined criteria []. Complete immunophenotype data in 3 patients was unavailable. Patients were considered as good prednisolone responder at day 8 if absolute blast counts (ABC) were < 1000/ul and poor prednisolone responder if ABC > 1000/ul. Day 8 ABC data was unavailable in6 cases. Patients were treated and followed up uniformly as per the ICiCLe treatment protocol (Clinical Trials Registry-India number, CTRI/2015/12/006,434) []. Written informed consent in agreement with the Declaration of Helsinki was taken from children and or guardians and the study was approved by the Institutional Ethics board."