Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma.

"Declarations Ethics approval The studies involving human participants were reviewed and approved by Ethics Committee of Xiangya Hospital, Central South University (2022020475). The animal ethics application was approved by the Experimental Animal Ethics Committee of Xiangya Hospital, Central South University (committee reference number: 2022020699) and performed following the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments, the U.K. Animals (Scientific Procedures) Act, 1986 and associated guidelines, EU Directive 2010/63/EU for animal experiments, and the National Research Council's Guide for the Care and Use of Laboratory Animals. The patients/participants provided their written informed consent to participate in this study. Consent to participateInformed consent was obtained from all individual participants included in the study. Competing interestsThe authors have no relevant financial or non-financial interests to disclose. Competing interests The authors have no relevant financial or non-financial interests to disclose."

"Funding This study was funded by the National Natural Science Foundation of China (82270033; 81873407; 82200039) and Natural Science Foundation of Hunan province (2022JJ30924; 2023JJ40947)."