TYROBP/DAP12 knockout in Huntington's disease Q175 mice cell-autonomously decreases microglial expression of disease-associated genes and non-cell-autonomously mitigates astrogliosis and motor deterioration.

"availability of data and materials raw data and processed information of the rna-seq experiments generated in this article were deposited at the gene expression omnibus repository under the accession numbers gse193573 (bulk rna-seq) and gse195633 (microglia rna-seq).; raw data and complete ms data sets have been uploaded to the center for computational mass spectrometry to the massive repository at ucsd and can be downloaded using the following link: ftp://massive ucsd edu/v07/msv000088643/ https://massive ucsd edu/proteosafe/dataset jsp? availability of data and materials raw data and processed information of the rna-seq experiments generated in this article were deposited at the gene expression omnibus repository under the accession numbers gse193573"

"Declarations Ethics approval and consent to participateNot applicable. Consent for publicationAll the authors consent to the publication of this study. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This research was supported by the National Institutes of Health | National Institute of Neurological Disorders and Stroke Grant R01-NS100529 (to L.M.E. and M.E.E.) and by the National Institute on Aging U01 AG046170 (to M.E.E). Support was also provided by “The Taube Family Program in Regenerative Medicine Genome Editing for Huntington’s Disease” to LME. We also acknowledge the support of instrumentation for the Orbitrap Eclipse Tribrid from the NCRR shared instrumentation grant 1S10 OD028654 (PI: Birgit Schilling)."