Activation of the PI3K/AKT signaling pathway by ARNTL2 enhances cellular glycolysis and sensitizes pancreatic adenocarcinoma to erlotinib.

"Declarations Ethics approval and consent to participateFresh pancreatic ductal adenocarcinoma tissue was obtained from patients who underwent surgical resection at Shanghai Renji Hospital with approval by the Ethics Committee of Renji Hospital, affiliated with Shanghai Jiao Tong University School of Medicine (Shanghai, China, KY [2019]035). Consent for publicationAll authors approved the final manuscript and the submission to this journal. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This research was funded by the National Natural Science Foundation of China (82272906; 82171824; 82103087; 82002625; 81972280); Scientific and Technological Innovation Project of Science and Technology Commission of Shanghai Municipality (21JC1404300); Innovation Group Project of Shanghai Municipal Health Commission (2019CXJQ03);Shanghai Municipal Commission of Health and Family Planning Grant 2018ZHYL0223; Shanghai Municipal Education Commission—Gao Feng Clinical Medicine Grant Support (20161312); Shanghai Key Clinical Specialty (Oncology); Shanghai Leading Talents Project; Clinical Research Plan of SHDC (No. SHDC2020CR1035B); Shanghai Sailing Program (20YF1446400); National Key R&D Program of China (2019YFC1315900); Project from CSCO Clinical Oncology Research Foundation (Y‐ 2019AZZD‐0513); and the Innovative Research Team of High‐Level Local Universities in Shanghai (SHSMU‐ZDCX20210802); Academic Leaders Training Program of Pudong Health Bureau of Shanghai [grant number PWRd2022-02]."