Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote gastric cancer progression.

"Declarations Ethics approval and consent to participateAll animal studies were performed in compliance with Shenzhen TopBiotech Co., Ltd. (Shenzhen, China) institutional animal care regulations and conducted according to the AAALAC and the IACUC guidelines (No. SYSU-IACUC-2023-B0965). All human gastric cancer plasma and tissues were obtained with written informed consent from patients or their guardians prior to participation in our research. The sample collection procedure was approved by the Sun Yat-sen University Health Science Institution Review Board (No. KY-2022–051-02). Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This study was supported by Guangdong Provincial Key Laboratory of Digestive Cancer Research (No. 2021B1212040006), Sanming Project of Medicine in Shenzhen (No. SZSM201911010), Shenzhen Key Medical Discipline Construction Fund (No.SZXK016), Guangdong-Hong Kong-Macau University Joint Laboratory of Digestive Cancer Research(No.2021LSYS003), the National Natural Science Foundation of China (Grant No. U20A20379, 82220108013, 82073148, 82200569 and 82102716), China Postdoctoral Science Foundation (2022M713588 and 2023M744016), Research start-up fund of part-time PI, SAHSYSU (ZSQYJZPI202001), Guangdong Basic and Applied Basic Research Foundation (2023A1515010473, 2021A1515111011), Shenzhen Excellent Science and Technology Innovation Talent Training Project (grant number RCBS20210706092410024), the Scientific Technology Project ofhenzhen City (JCYJ20220530144815035), and the Open Fund of Guangdong Provincial Key Laboratory of Digestive Cancer Research (2021B1212040006)."