ANGPTL3 is a novel HDL component that regulates HDL function.

"Declarations Ethics approval and consent to participateThis study complied with the Helsinki Declaration for investigation of human subjects and received approval from the Ethics Committee of Beijing Luhe Hospital Capital Medical University. All experiments were performed in accordance with the Health Guide for the Care and Use of Laboratory Animals and were approved by the competent Institutional Review Boards of Capital Medical University. Consent for publicationAll authors read and approved the final manuscript. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This study received support from the National Science Funding in China (81800768 and 82170454), Beijing Natural Science Foundation (7184222) and Tongzhou District Science and Technology Project (KJ2023CX036 and KJ2022CX017)."