Mapping the metabolic responses to oxaliplatin-based chemotherapy with <i>in vivo</i> spatiotemporal metabolomics.

"Declaration of competing interest The authors declare that there are no conflicts of interest."

"This study was supported by the Canadian Institute of Health Research (CIHR)–Natural Sciences and Engineering Research Council (NSERC) of Canada Collaborative Health Research Projects program (Grant No.: 355935), as well as by NSERC through the Industrial Research Chair (IRC) program (Program No.: #IRCPJ 184412e15). The funders had no role in the study design, data collection and analysis, decision to publish, or manuscript preparation. We would also like to thank Supelco (Oakville, ON, Canada) for the MM and C18 SPME fibres, as well as the analytical columns that were used in this study. Mariola Olkowicz: Conceptualization, Methodology, Validation, Formal analysis, Investigation, Data curation, Writing - Original draft preparation, and Reviewing and Editing, Visualization; Khaled Ramadan: Conceptualization, Methodology, Validation, Formal analysis, Investigation, Data curation, Writing - Reviewing and Editing; Hernando Rosales-Solano: Methodology, Formal analysis, Investigation, Writing - Reviewing and Editing; Miao Yu: Software, Validation, Formal analysis, Investigation, Data curation, Writing - Reviewing and Editing; Aizhou Wang: Methodology, Investigation, Writing - Reviewing and Editing; Marcelo Cypel: Conceptualization, Supervision, Funding acquisition, Resources, Project administration, Writing - Reviewing and Editing; Janusz Pawliszyn: Conceptualization, Supervision, Funding acquisition, Resources, Project administration, Writing - Reviewing and Editing."