Pyrimethamine upregulates BNIP3 to interfere SNARE-mediated autophagosome-lysosomal fusion in hepatocellular carcinoma.

"Declaration of competing interest The authors declare that there are no conflicts of interest."

"This work was supported by the 10.13039/501100001809National Natural Science Foundation of China (Grant No: 81903643), the “Young Talent Support Plan” of Xi'an Jiaotong University, the Shaanxi Province Science and Technology Development Plan Project (Grant No.: 2022ZDLSF05-05), the Project of Shaanxi Provincial Administration of Traditional Chinese Medicine (Project No.: 2021-03-ZZ-002), and the Shaanxi Province Science Fund for Distinguished Young Scholars (Grant No: 2023-JC-JQ-59). We also thank Miss Ying Hao of the Instrument Analysis Center of Xi'an Jiaotong University for her assistance with super-resolution confocal microscopy. Jingjing Wang: Conceptualization, Methodology, Visualization, Formal analysis, Data curation, Writing - Original draft preparation; Qi Su: Conceptualization, Supervision, Funding acquisition; Kun Chen: Software, Formal analysis, Investigation; Qing Wu: Software, Visualization; Jiayan Ren: Methodology, Validation; Wenjuan Tang: Resources, Visualization; Yu Hu: Investigation, Validation; Zeren Zhu: Methodology, Validation; Cheng Cheng: Methodology, Validation; Kaihui Tu: Methodology, Validation; Huaizhen He: Investigation, Validation; Yanmin Zhang: Supervision, Project administration, Funding acquisition."