Functional polymorphisms of <i>NOS3</i> and <i>GUCY1A3</i> affect both nitric oxide formation and association with hypertensive disorders of pregnancy.

"Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision."

"The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This study was supported by the National Council for Scientific and Technological Development (CNPq/Brazil; grants #314486/2023-2 and #308504/2021-6), the São Paulo Research Foundation (FAPESP/Brazil; grants #2019/07230-8 and #2021/12010-7), the Coordination for the Improvement of Higher Education Personnel (CAPES/Brazil) (finance code 001), and the National Institutes of Health (NIH/USA; grants K01HL159032, R01HL148191, and U54GM115428)."