Whole-exome sequencing combined with postoperative data identify c.1614dup (CAMKK2) as a novel candidate monogenic obesity variant.

"Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest."

"The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by The National Natural Science Foundation of China (82370884, 82170887)."

"Obese patients (BMI >30kg/m2) who underwent bariatric surgery at the Gastrointestinal Minimally Invasive Center of the Third People’s Hospital of Chengdu during years of 2021 to 2022 were selected. The early-onset obesity group included subjects who were obese before 10 years old while the control group were after, according to the criteria of the Working Group for Obesity in China (WGOC) (). Finally, a total of 62 early-onset obesity and 9 controls were included. Patient blood samples were collected, and preoperative clinical data and postoperative follow-up information were recorded. All procedures involving human subjects were approved by the Ethics Committee of The Third People’s Hospital of Chengdu. The clinical trial registration number is ChiCTR2300073353. The volunteers were provided with full information about the study, and their informed consent was obtained."