Abnormal functional lymphoid tolerance and enhanced myeloid exocytosis are characteristics of resting and stimulated PBMCs in cystic fibrosis patients.

"Conflict of interest Author IS-G reports support for the present manuscript from Vaincre la Mucoviscidose and Mucoviscidose ABCF2. Author IS-G also reports, outside the submitted work, grants from Agence Nationale pour la Recherche, Assistance Publique– Hôpitaux de Paris and Vertex Innovation Award, and consulting fees and travel support from Vertex therapeutics. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision."

"The author(s) declare financial support was received for the research, authorship, and/or publication of this article. CG, RG, FL were financed by Vaincre la Mucoviscidose/VLM and the fund ‘Blanche pour vaincre la mucoviscidose’ (grants RF20180502230, RF20190502480, RF20170502002)."