Combined Effect of Early Nutrition Therapy and Rehabilitation for Patients with Chronic Obstructive Pulmonary Disease Exacerbation: A Prospective Randomized Controlled Trial.

"Conflicts of Interest H.T. received lecture fees from Tsumura & Co. and an industry–academia collaborative research grant from Otsuka Pharmaceutical Factory, Inc. Y.M. received lecture fees from MSD K.K., Asahi Kasei Pharma Corp., Japan Blood Product, and an industry–academia collaborative research grant from Jimro Co., Ltd. The authors declare no conflicts of interest."

"This research received no external funding."

"This study was conducted in compliance with the ethical guidelines for medical research involving human participants and in accordance with the principles set forth in the Declaration of Helsinki. The participants were provided a full explanation in advance by the researcher, and those who agreed to participate provided written informed consent. Participants who did not provide informed consent were excluded from the study. This study was approved by the Ethics Review Committee of the Japan Regional Medical Organization Hokkaido Hospital (approval number 2019-11, 19 August 2019) and registered in the public clinical trial registry (registration number of clinical trial, UMIN000037984) before the first patient was included. The study protocol describes the detailed course of the study and is available online on the website “https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000043285 (accessed on 30 October 2023)”."