Association between missense variants of uncertain significance in the <i>CHEK2</i> gene and hereditary breast cancer: a cosegregation and bioinformatics analysis.

"even though no full-length structure experimentally solved is available partial high-resolution structures of chk2 encompassing the fha or kinase domain have been released e g pdb 1gxc (2 7 a residues92-207) ( ) and pdb 2cn5 (2 25 a residues210-504) ( ).; figure 4 chk2 structure domains and main features (a) chk2 structure (cartoon) with the highest coverage (homodimeric biological unit) released in pdb 3i6u ( ) (b) fha domain (pdb 1gcx ( ) cartoon) with the mutation spots of the vus highlighted in orange (sticks) and the flexible long loop highlighted in magenta."

"Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest."

"The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The authors received financial support from grants PID 2019-107293 GB-I00, PID 2022-141068NB-I00 (MICINN, Spain), and E45_23R (Gobierno de Aragón, Spain)."