Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)

"at the nucleotide level this transcript is85% homologous to a human zinc finger protein (sequence data available from embl/genbank/ddbj under accession no u18543 ) known to interact with the activation domain of lentiviral tat proteins ( ).; the human toll-like receptor 4 gene ( tlr4 ; sequence data available from embl/genbank/ddbj under accession no u93091 ) maps to chromosome 9q32-33 and is a member of an emerging family of molecules implicated in innate immune recognition ( ).; these sequence data are available from embl/ genbank/ddbj under accession no af110133 ."

"This work was supported by research grants to D. Malo from the Medical Research Council of Canada and to D. Malo and P. Gros from Millennium Pharmaceuticals Inc. D. Malo is a Scholar of Fonds de la Recherche en Santé du Québec, and P. Gros is an International Research Scholar of the Howard Hughes Medical Institute and a Senior Scientist of the Medical Research Council of Canada. S.T. Qureshi is a recipient of a Clinician Scientist Award from the Medical Research Council of Canada and a Career Award in the Biomedical Sciences from the Burroughs Wellcome Fund."