Research Papers

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Advanced Pyrrolidine-Carbamate Self-Immolative Spacer with Tertiary Amine Handle Induces Superfast Cyclative Drug Relea…
Dal Corso A; Frigoli M; Prevosti M; Mason M; Bucci R; Belvisi L; Pignataro L; Gennari C.
ChemMedChem (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
Spirooxindol-1,3-oxazine Alkaloids: Highly Potent and Selective Antitumor Agents Evolved from Iterative Structure Optim…
Eichhorst A; Gallhof M; Voss A; Sekora A; Eggers L; Huyen LT; Junghanss C; Murua Escobar H; Brasholz M.
ChemMedChem (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
Structural Considerations for Building Synthetic Glycoconjugates as Inhibitors for Pseudomonas aeruginosa Lectins.
Wojtczak K; Byrne JP.
ChemMedChem (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
Structure-Based Virtual Screening and in vitro and in vivo Analyses Revealed Potent Methyltransferase G9a Inhibitors as…
Bellver-Sanchis A; Singh Choudhary B; Companys-Alemany J; Sukanya; Ávila-López PA; Martínez Rodríguez AL; Brea Floriani JM; Malik R; Pallàs M; Pérez B; Griñán-Ferré C.
ChemMedChem (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
Synthesis, in vitro Antileishmanial Efficacy and Hit/Lead Identification of Nitrofurantoin-Triazole Hybrids.
Zuma NH; Aucamp J; Viljoen M; N'Da DD.
ChemMedChem (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
Evaluation of a Radiolabeled Macrocyclic Peptide as Potential PET Imaging Probe for PD-L1.
Jouini N; Cardinale J; Mindt TL.
ChemMedChem (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
Oxygenating Biocatalysts for Hydroxyl Functionalisation in Drug Discovery and Development.
Charlton SN; Hayes MA.
ChemMedChem (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
Conjugates of Tacrine with Salicylamide as Promising Multitarget Agents for Alzheimer's Disease.
Grishchenko MV; Makhaeva GF; Burgart YV; Rudakova EV; Boltneva NP; Kovaleva NV; Serebryakova OG; Lushchekina SV; Astakhova TY; Zhilina EF; Shchegolkov EV; Richardson RJ; Saloutin VI.
ChemMedChem (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
Puckering the Planar Landscape of Fragments: Design and Synthesis of a 3D Cyclobutane Fragment Library.
Hamilton DJ; Beemsterboer M; Carter CM; Elsayed J; Huiberts REM; Klein HF; O'Brien P; de Esch IJP; Wijtmans M.
ChemMedChem (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
Selenocarbamates As a Prodrug-Based Approach to Carbonic Anhydrase Inhibition.
Angeli A; Ferraroni M; Capperucci A; Tanini D; Costantino G; Supuran CT.
ChemMedChem (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
2-Amino-4-aryl-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carbonitriles with Microtubule-Disruptive, Centrosome-Decluster…
Köhler LHF; Reich S; Begemann G; Schobert R; Biersack B.
ChemMedChem (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
Complex pBAE Nanoparticle Cell Trafficking: Tracking Both Position and Composition Using Super Resolution Microscopy.
Riera R; Tauler J; Feiner-Gracia N; Borrós S; Fornaguera C; Albertazzi L.
ChemMedChem (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
Disrupting Transcription and Folate Biosynthesis Leads to Synergistic Suppression of Escherichia coli Growth.
Chen PH; Sung LK; Hegemann JD; Chu J.
ChemMedChem (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
Multidrug Idebenone/Naproxen Co-loaded Aspasomes for Significant in vivo Anti-inflammatory Activity.
d'Avanzo N; Cristiano MC; Di Marzio L; Bruno MC; Paolino D; Celia C; Fresta M.
ChemMedChem (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
Expanding the Repertoire of Low-Molecular-Weight Pentafluorosulfanyl-Substituted Scaffolds.
Jose A; Guest D; LeGay R; Tizzard GJ; Coles SJ; Derveni M; Wright E; Marrison L; Lee AA; Morris A; Robinson M; von Delft F; Fearon D; Koekemoer L; Matviuk T; Aimon A; Schofield CJ; Malla TR; London N; Greenland BW; Bagley MC; Spencer J; The Covid Moonshot Consortium.
ChemMedChem (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
Synthesis and in vitro Study of Artemisinin/Synthetic Peroxide-Based Hybrid Compounds against SARS-CoV-2 and Cancer.
Herrmann L; Yaremenko IA; Çapcı A; Struwe J; Tailor D; Dheeraj A; Hodek J; Belyakova YY; Radulov PS; Weber J; Malhotra SV; Terent'ev AO; Ackermann L; Tsogoeva SB.
ChemMedChem (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
Covalent Allosteric Inhibitors of Akt Generated Using a Click Fragment Approach.
van der Westhuizen L; Weisner J; Taher A; Landel I; Quambusch L; Lindemann M; Uhlenbrock N; Müller MP; Green IR; Pelly SC; Rauh D; van Otterlo WAL.
ChemMedChem (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
New Insight into Dearomatization and Decarbonylation of Antitubercular 4H-Benzo[e][1,3]thiazinones: Stable 5H- and 7H-B…
Richter A; Seidel RW; Graf J; Goddard R; Lehmann C; Schlegel T; Khater N; Imming P.
ChemMedChem (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
Andrographolide Derivatives Target the KEAP1/NRF2 Axis and Possess Potent Anti-SARS-CoV-2 Activity.
Schulte B; König M; Escher BI; Wittenburg S; Proj M; Wolf V; Lemke C; Schnakenburg G; Sosič I; Streeck H; Müller CE; Gütschow M; Steinebach C.
ChemMedChem (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
Synthesis of Aminoethyl-Substituted Piperidine Derivatives as σ<sub>1</sub> Receptor Ligands with Antiproliferative Pro…
Holtschulte C; Börgel F; Westphälinger S; Schepmann D; Civenni G; Laurini E; Marson D; Catapano CV; Pricl S; Wünsch B.
ChemMedChem (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
Chemically Tuned Intracellular Gene Delivery by Core-Shell Nanoparticles: Effects of Proton Buffering, Acid Degradabili…
Cho SK; Lee RT; Hwang YH; Kwon YJ.
ChemMedChem (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
Mapping the Binding Sites of UDP and Prostaglandin E2 Glyceryl Ester in the Nucleotide Receptor P2Y<sub>6</sub>.
Zimmermann A; Vu O; Brüser A; Sliwoski G; Marnett LJ; Meiler J; Schöneberg T.
ChemMedChem (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
Selective Binding of Small Molecules to Vibrio cholerae DsbA Offers a Starting Point for the Design of Novel Antibacter…
Wang G; Mohanty B; Williams ML; Doak BC; Dhouib R; Totsika M; McMahon RM; Sharma G; Zheng D; Bentley MR; Ka-Yan Chin Y; Horne J; Chalmers DK; Heras B; Scanlon MJ.
ChemMedChem (Unknown)
Published: 2022
4/6 Transparent
Data Funding Declared
Targeting the IspD Enzyme in the MEP Pathway: Identification of a Novel Fragment Class.
Diamanti E; Hamed MM; Lacour A; Bravo P; Illarionov B; Fischer M; Rottmann M; Witschel M; Hirsch AKH.
ChemMedChem (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
Interaction of Copper Trafficking Proteins with the Platinum Anticancer Drug Kiteplatin.
Barbanente A; Galliani A; Iacobazzi RM; Lasorsa A; Nardella MI; Pennetta A; Margiotta N; Arnesano F.
ChemMedChem (Unknown)
Published: 2021
2/6 Transparent
Funding Declared