Research Papers

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Multi-endpoint analysis of cadmium chloride-induced genotoxicity shows role for reactive oxygen species and p53 activat…
Stannard LM; Doherty A; Chapman KE; Doak SH; Jenkins GJ.
Mutagenesis (Unknown)
Published: 2024
3/6 Transparent
Funding Declared
Impact of mobile phone-specific electromagnetic fields on DNA damage caused by occupationally relevant exposures: resul…
Mišík M; Kundi M; Worel N; Ferk F; Hutter HP; Grusch M; Nersesyan A; Herrera Morales D; Knasmueller S.
Mutagenesis (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
Evaluation of endpoints for the study and diagnosis of mitochondrial toxicity and disease: a narrative review.
Gharti P; Fletcher JF; Chapman KE.
Mutagenesis (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
Measuring blood cell DNA damage using the PIG-A mutation and CBMN assay in pancreatic cancer patients: a pilot study.
Nichols L; Lawrence R; Haboubi H; Al-Sarireh B; Doak S; Jenkins G.
Mutagenesis (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
Ex vivo explant model of adenoma and colorectal cancer to explore mechanisms of action and patient response to cancer p…
Khan S; Miles GJ; Demetriou C; Sidat Z; Foreman N; West K; Karmokar A; Howells L; Pritchard C; Thomas AL; Brown K.
Mutagenesis (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
A novel in vitro 3D model of the human bone marrow to bridge the gap between in vitro and in vivo genotoxicity testing.
Vernon AR; Pemberton RM; Morse HR.
Mutagenesis (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
Organoids for toxicology and genetic toxicology: applications with drugs and prospects for environmental carcinogenesis.
Caipa Garcia AL; Arlt VM; Phillips DH.
Mutagenesis (Unknown)
Published: 2022
3/6 Transparent
Funding Declared
Expression pattern and prognostic value of N6-methyladenosine RNA methylation key regulators in hepatocellular carcinom…
Deng M; Fang L; Li SH; Zhao RC; Mei J; Zou JW; Wei W; Guo RP.
Mutagenesis (Unknown)
Published: 2021
2/6 Transparent
Funding Declared
Mlh1 heterozygosity and promoter methylation associates with microsatellite instability in mouse sperm.
Shrestha KS; Tuominen MM; Kauppi L.
Mutagenesis (Unknown)
Published: 2021
2/6 Transparent
Funding Declared
Validation of the 3D reconstructed human skin micronucleus (RSMN) assay: an animal-free alternative for following-up po…
Pfuhler S; Downs TR; Hewitt NJ; Hoffmann S; Mun GC; Ouedraogo G; Roy S; Curren RD; Aardema MJ.
Mutagenesis (Unknown)
Published: 2021
2/6 Transparent
Funding Declared
Validation of the 3D reconstructed human skin Comet assay, an animal-free alternative for following-up positive results…
Pfuhler S; Pirow R; Downs TR; Haase A; Hewitt N; Luch A; Merkel M; Petrick C; Said A; Schäfer-Korting M; Reisinger K.
Mutagenesis (Unknown)
Published: 2021
2/6 Transparent
Funding Declared
Effect of 2-acetylaminofluorene and its genotoxic metabolites on DNA adduct formation and DNA damage in 3D reconstructe…
Downs TR; Arlt VM; Barnett BC; Posgai R; Pfuhler S.
Mutagenesis (Unknown)
Published: 2021
3/6 Transparent
Funding Declared
The impact of p53 function on the metabolic activation of the carcinogenic air pollutant 3-nitrobenzanthrone and its me…
Wohak LE; Baranski AC; Krais AM; Schmeiser HH; Phillips DH; Arlt VM.
Mutagenesis (Unknown)
Published: 2018
2/6 Transparent
Funding Declared
Quantitative relationships between lacZ mutant frequency and DNA adduct frequency in Muta™Mouse tissues and cultured ce…
White PA; Douglas GR; Phillips DH; Arlt VM.
Mutagenesis (Unknown)
Published: 2017
2/6 Transparent
Funding Declared
Development of an in vitro PIG-A gene mutation assay in human cells.
Rees BJ; Tate M; Lynch AM; Thornton CA; Jenkins GJ; Walmsley RM; Johnson GE.
Mutagenesis (Unknown)
Published: 2017
2/6 Transparent
Funding Declared
Critical review of the current and future challenges associated with advanced in vitro systems towards the study of nan…
Evans SJ; Clift MJ; Singh N; de Oliveira Mallia J; Burgum M; Wills JW; Wilkinson TS; Jenkins GJ; Doak SH.
Mutagenesis (Unknown)
Published: 2016
2/6 Transparent
Funding Declared
Diet-sourced carbon-based nanoparticles induce lipid alterations in tissues of zebrafish (Danio rerio) with genomic hyp…
Gorrochategui E; Li J; Fullwood NJ; Ying GG; Tian M; Cui L; Shen H; Lacorte S; Tauler R; Martin FL.
Mutagenesis (Unknown)
Published: 2016
3/6 Transparent
Data Funding Declared
Toxicogenomics analysis of mouse lung responses following exposure to titanium dioxide nanomaterials reveal their disea…
Rahman L; Wu D; Johnston M; William A; Halappanavar S.
Mutagenesis (Unknown)
Published: 2016
3/6 Transparent
Data Funding Declared
Surface modification does not influence the genotoxic and inflammatory effects of TiO2 nanoparticles after pulmonary ex…
Wallin H; Kyjovska ZO; Poulsen SS; Jacobsen NR; Saber AT; Bengtson S; Jackson P; Vogel U.
Mutagenesis (Unknown)
Published: 2016
2/6 Transparent
Funding Declared
Genotoxicity of TiO2 nanoparticles assessed by mini-gel comet assay and micronucleus scoring with flow cytometry.
Di Bucchianico S; Cappellini F; Le Bihanic F; Zhang Y; Dreij K; Karlsson HL.
Mutagenesis (Unknown)
Published: 2016
1/6 Transparent
Funding Declared
The genome as a record of environmental exposure.
Nik-Zainal S; Kucab JE; Morganella S; Glodzik D; Alexandrov LB; Arlt VM; Weninger A; Hollstein M; Stratton MR; Phillips DH.
Mutagenesis (Unknown)
Published: 2015
1/6 Transparent
Funding Declared
Genotoxicity of flubendazole and its metabolites in vitro and the impact of a new formulation on in vivo aneugenicity.
Tweats DJ; Johnson GE; Scandale I; Whitwell J; Evans DB.
Mutagenesis (Unknown)
Published: 2015
1/6 Transparent
Funding Declared
The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency.
Brüsehafer K; Manshian BB; Doherty AT; Zaïr ZM; Johnson GE; Doak SH; Jenkins GJ.
Mutagenesis (Unknown)
Published: 2015
2/6 Transparent
Funding Declared
Genotoxic capacity of Cd/Se semiconductor quantum dots with differing surface chemistries.
Manshian BB; Soenen SJ; Brown A; Hondow N; Wills J; Jenkins GJ; Doak SH.
Mutagenesis (Unknown)
Published: 2015
2/6 Transparent
Funding Declared
Cytotoxicity and genotoxicity of urban particulate matter in mammalian cells.
Dumax-Vorzet AF; Tate M; Walmsley R; Elder RH; Povey AC.
Mutagenesis (Unknown)
Published: 2015
2/6 Transparent
Funding Declared