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Proteolytic activation of fatty acid synthase signals pan-stress resolution.
Nat Metab
(Unknown)
Published: 2024
Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype.
Maus M; López-Polo V; Mateo L; Lafarga M; Aguilera M; De Lama E; Meyer K; Sola A; Lopez-Martinez C; López-Alonso I; Guasch-Piqueras M; Hernandez-Gonzalez F; Chaib S; Rovira M; Sanchez M; Faner R; Agusti A; Diéguez-Hurtado R; Ortega S; Manonelles A; Engelhardt S; Monteiro F; Stephan-Otto Attolini C; Prats N; Albaiceta G; Cruzado JM; Serrano M.
Nat Metab
(Unknown)
Published: 2023
Vitamin B<sub>12</sub> is a limiting factor for induced cellular plasticity and tissue repair.
Kovatcheva M; Melendez E; Chondronasiou D; Pietrocola F; Bernad R; Caballe A; Junza A; Capellades J; Holguín-Horcajo A; Prats N; Durand S; Rovira M; Yanes O; Stephan-Otto Attolini C; Kroemer G; Serrano M.
Nat Metab
(Unknown)
Published: 2023
Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice.
Liskiewicz A; Khalil A; Liskiewicz D; Novikoff A; Grandl G; Maity-Kumar G; Gutgesell RM; Bakhti M; Bastidas-Ponce A; Czarnecki O; Makris K; Lickert H; Feuchtinger A; Tost M; Coupland C; Ständer L; Akindehin S; Prakash S; Abrar F; Castelino RL; He Y; Knerr PJ; Yang B; Hogendorf WFJ; Zhang S; Hofmann SM; Finan B; DiMarchi RD; Tschöp MH; Douros JD; Müller TD.
Nat Metab
(Unknown)
Published: 2023
Vitamin B<sub>5</sub> supports MYC oncogenic metabolism and tumor progression in breast cancer.
Kreuzaler P; Inglese P; Ghanate A; Gjelaj E; Wu V; Panina Y; Mendez-Lucas A; MacLachlan C; Patani N; Hubert CB; Huang H; Greenidge G; Rueda OM; Taylor AJ; Karali E; Kazanc E; Spicer A; Dexter A; Lin W; Thompson D; Silva Dos Santos M; Calvani E; Legrave N; Ellis JK; Greenwood W; Green M; Nye E; Still E; CRUK Rosetta Grand Challenge Consortium; Barry S; Goodwin RJA; Bruna A; Caldas C; MacRae J; de Carvalho LPS; Poulogiannis G; McMahon G; Takats Z; Bunch J; Yuneva M.
Nat Metab
(Unknown)
Published: 2023
The glucose transporter 2 regulates CD8<sup>+</sup> T cell function via environment sensing.
Fu H; Vuononvirta J; Fanti S; Bonacina F; D'Amati A; Wang G; Poobalasingam T; Fankhaenel M; Lucchesi D; Coleby R; Tarussio D; Thorens B; Hearnden RJ; Longhi MP; Grevitt P; Sheikh MH; Solito E; Godinho SA; Bombardieri M; Smith DM; Cooper D; Iqbal AJ; Rathmell JC; Schaefer S; Morales V; Bianchi K; Norata GD; Marelli-Berg FM.
Nat Metab
(Unknown)
Published: 2023
Upregulation of WDR6 drives hepatic de novo lipogenesis in insulin resistance in mice.
Yao Z; Gong Y; Chen W; Shao S; Song Y; Guo H; Li Q; Liu S; Wang X; Zhang Z; Wang Q; Xu Y; Wu Y; Wan Q; Zhao X; Xuan Q; Wang D; Lin X; Xu J; Liu J; Proud CG; Wang X; Yang R; Fu L; Niu S; Kong J; Gao L; Bo T; Zhao J.
Nat Metab
(Unknown)
Published: 2023
Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target.
Vande Voorde J; Steven RT; Najumudeen AK; Ford CA; Dexter A; Gonzalez-Fernandez A; Nikula CJ; Xiang Y; Ford L; Maneta Stavrakaki S; Gilroy K; Zeiger LB; Pennel K; Hatthakarnkul P; Elia EA; Nasif A; Murta T; Manoli E; Mason S; Gillespie M; Lannagan TRM; Vlahov N; Ridgway RA; Nixon C; Raven A; Mills M; Athineos D; Kanellos G; Nourse C; Gay DM; Hughes M; Burton A; Yan B; Sellers K; Wu V; De Ridder K; Shokry E; Huerta Uribe A; Clark W; Clark G; Kirschner K; Thienpont B; Li VSW; Maddocks ODK; Barry ST; Goodwin RJA; Kinross J; Edwards J; Yuneva MO; Sumpton D; Takats Z; Campbell AD; Bunch J; Sansom OJ.
Nat Metab
(Unknown)
Published: 2023
Metabolic rewiring induced by ranolazine improves melanoma responses to targeted therapy and immunotherapy.
Redondo-Muñoz M; Rodriguez-Baena FJ; Aldaz P; Caballé-Mestres A; Moncho-Amor V; Otaegi-Ugartemendia M; Carrasco-Garcia E; Olias-Arjona A; Lasheras-Otero I; Santamaria E; Bocanegra A; Chocarro L; Grier A; Dzieciatkowska M M; Bigas C; Martin J; Urdiroz-Urricelqui U; Marzo F; Santamaria E; Kochan G; Escors D; Larrayoz IM; Heyn H; D'Alessandro A; Attolini CS; Matheu A; Wellbrock C; Benitah SA; Sanchez-Laorden B; Arozarena I.
Nat Metab
(Unknown)
Published: 2023
Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota.
Ji M; Xu X; Xu Q; Hsiao YC; Martin C; Ukraintseva S; Popov V; Arbeev KG; Randall TA; Wu X; Garcia-Peterson LM; Liu J; Xu X; Andrea Azcarate-Peril M; Wan Y; Yashin AI; Anantharaman K; Lu K; Li JL; Shats I; Li X.
Nat Metab
(Unknown)
Published: 2023
Fatty acid oxidation organizes mitochondrial supercomplexes to sustain astrocytic ROS and cognition.
Morant-Ferrando B; Jimenez-Blasco D; Alonso-Batan P; Agulla J; Lapresa R; Garcia-Rodriguez D; Yunta-Sanchez S; Lopez-Fabuel I; Fernandez E; Carmeliet P; Almeida A; Garcia-Macia M; Bolaños JP.
Nat Metab
(Unknown)
Published: 2023
Commensal bacteria weaken the intestinal barrier by suppressing epithelial neuropilin-1 and Hedgehog signaling.
Pontarollo G; Kollar B; Mann A; Khuu MP; Kiouptsi K; Bayer F; Brandão I; Zinina VV; Hahlbrock J; Malinarich F; Mimmler M; Bhushan S; Marini F; Ruf W; Belheouane M; Baines JF; Endres K; Reba SM; Raker VK; Deppermann C; Welsch C; Bosmann M; Soshnikova N; Chassaing B; Bergentall M; Sommer F; Bäckhed F; Reinhardt C.
Nat Metab
(Unknown)
Published: 2023
The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets.
El K; Douros JD; Willard FS; Novikoff A; Sargsyan A; Perez-Tilve D; Wainscott DB; Yang B; Chen A; Wothe D; Coupland C; Tschöp MH; Finan B; D'Alessio DA; Sloop KW; Müller TD; Campbell JE.
Nat Metab
(Unknown)
Published: 2023
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells.
Green AC; Marttila P; Kiweler N; Chalkiadaki C; Wiita E; Cookson V; Lesur A; Eiden K; Bernardin F; Vallin KSA; Borhade S; Long M; Ghahe EK; Jiménez-Alonso JJ; Jemth AS; Loseva O; Mortusewicz O; Meyers M; Viry E; Johansson AI; Hodek O; Homan E; Bonagas N; Ramos L; Sandberg L; Frödin M; Moussay E; Slipicevic A; Letellier E; Paggetti J; Sørensen CS; Helleday T; Henriksson M; Meiser J.
Nat Metab
(Unknown)
Published: 2023
Triglyceride cycling enables modification of stored fatty acids.
Nat Metab
(Unknown)
Published: 2023