Research Papers

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Discovery of a potent and selective cell division cycle 7 inhibitor from 6-(3-fluoropyridin-4-yl)thieno[3,2-<i>d</i>]py…
Fu M; Ge M; Yang W; Hu C; Li X; Wang Y; Gou S.
Acta Pharm Sin B (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
Transfer learning enhanced graph neural network for aldehyde oxidase metabolism prediction and its experimental applica…
Xiong J; Cui R; Li Z; Zhang W; Zhang R; Fu Z; Liu X; Li Z; Chen K; Zheng M.
Acta Pharm Sin B (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies.
Peng X; Hu Z; Zeng L; Zhang M; Xu C; Lu B; Tao C; Chen W; Hou W; Cheng K; Bi H; Pan W; Chen J.
Acta Pharm Sin B (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
pH-Responsive polymer boosts cytosolic siRNA release for retinal neovascularization therapy.
Guo S; Li C; Wang C; Cao X; Liu X; Liang XJ; Huang Y; Weng Y.
Acta Pharm Sin B (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
GLUL stabilizes N-Cadherin by antagonizing <i>β</i>-Catenin to inhibit the progresses of gastric cancer.
Jiang Q; Li Y; Cai S; Shi X; Yang Y; Xing Z; He Z; Wang S; Su Y; Chen M; Chen Z; Shi Z.
Acta Pharm Sin B (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
Selective type II TRK inhibitors overcome xDFG mutation mediated acquired resistance to the second-generation inhibitor…
Xiang S; Lu X.
Acta Pharm Sin B (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
Broad-spectrum ginsentides are principal bioactives in unraveling the cure-all effects of ginseng.
Loo S; Kam A; Dutta B; Zhang X; Feng N; Sze SK; Liu CF; Wang X; Tam JP.
Acta Pharm Sin B (Unknown)
Published: 2023
4/6 Transparent
Data Funding Declared
Metabolic basis of solute carrier transporters in treatment of type 2 diabetes mellitus.
Le J; Chen Y; Yang W; Chen L; Ye J.
Acta Pharm Sin B (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
Logic-gated tumor-microenvironment nanoamplifier enables targeted delivery of CRISPR/Cas9 for multimodal cancer therapy.
Pan Y; Luan X; Zeng F; Wang X; Qin S; Lu Q; He G; Gao Y; Sun X; Han X; He B; Song Y.
Acta Pharm Sin B (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
<i>miR-429-3p</i> mediates memory decline by targeting MKP-1 to reduce surface GluA1-containing AMPA receptors in a mou…
Luo M; Pang Y; Li J; Yi L; Wu B; Tian Q; He Y; Wang M; Xia L; He G; Song W; Du Y; Dong Z.
Acta Pharm Sin B (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
Evolution of chemistry and selection technology for DNA-encoded library.
Ma P; Zhang S; Huang Q; Gu Y; Zhou Z; Hou W; Yi W; Xu H.
Acta Pharm Sin B (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
Development of Chinese herbal medicine for sensorineural hearing loss.
Wu Y; Zhang J; Liu Q; Miao Z; Chai R; Chen W.
Acta Pharm Sin B (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
Targeting cAMP in D1-MSNs in the nucleus accumbens, a new rapid antidepressant strategy.
Zhang Y; Gao J; Li N; Xu P; Qu S; Cheng J; Wang M; Li X; Song Y; Xiao F; Yang X; Liu J; Hong H; Mu R; Li X; Wang Y; Xu H; Xie Y; Gao T; Wang G; Aa J.
Acta Pharm Sin B (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
Trilogy of drug repurposing for developing cancer and chemotherapy-induced heart failure co-therapy agent.
Chen X; Mu X; Ding L; Wang X; Mao F; Wei J; Liu Q; Xu Y; Ni S; Jia L; Li J.
Acta Pharm Sin B (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
Mechanism of action of the bile acid receptor TGR5 in obesity.
Lun W; Yan Q; Guo X; Zhou M; Bai Y; He J; Cao H; Che Q; Guo J; Su Z.
Acta Pharm Sin B (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
Targeting FAP<i>α</i>-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis.
Fan S; Qi M; Qi Q; Miao Q; Deng L; Pan J; Qiu S; He J; Huang M; Li X; Huang J; Lin J; Lyu W; Deng W; He Y; Liu X; Gao L; Zhang D; Ye W; Chen M.
Acta Pharm Sin B (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
Phosphatidic acid-enabled MKL1 contributes to liver regeneration: Translational implication in liver failure.
Zhou J; Sun X; Chen X; Liu H; Miao X; Guo Y; Fan Z; Li J; Xu Y; Li Z.
Acta Pharm Sin B (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
Structure-based development of potent and selective type-II kinase inhibitors of RIPK1.
Qin Y; Li D; Qi C; Xiang H; Meng H; Liu J; Zhou S; Gong X; Li Y; Xu G; Zu R; Xie H; Xu Y; Xu G; Zhang Z; Chen S; Pan L; Li Y; Tan L.
Acta Pharm Sin B (Unknown)
Published: 2023
4/6 Transparent
Data Funding Declared
Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin: Creation of an unnatural analogue wi…
Yan D; Arakelyan J; Wan T; Raina R; Chan TK; Ahn D; Kushnarev V; Cheung TK; Chan HC; Choi I; Ho PY; Hu F; Kim Y; Lau HL; Law YL; Leung CS; Tong CY; Wong KK; Yim WL; Karnaukhov NS; Kong RYC; Babak MV; Matsuda Y.
Acta Pharm Sin B (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
A novel TNKS/USP25 inhibitor blocks the Wnt pathway to overcome multi-drug resistance in TNKS-overexpressing colorectal…
Zhu H; Gao Y; Liu L; Tao M; Lin X; Cheng Y; Shen Y; Xue H; Guan L; Zhao H; Liu L; Wang S; Yang F; Zhou Y; Liao H; Sun F; Lin H.
Acta Pharm Sin B (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
Commentary: Gut microbiota reduce the risk of hyperuricemia and gout in the human body.
Wang L; Ye J.
Acta Pharm Sin B (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
GRK2 inhibits Flt-1<sup>+</sup> macrophage infiltration and its proangiogenic properties in rheumatoid arthritis.
Yang X; Zhao Y; Wei Q; Zhu X; Wang L; Zhang W; Liu X; Kuai J; Wang F; Wei W.
Acta Pharm Sin B (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
Visualization of nasal powder distribution using biomimetic human nasal cavity model.
Su J; Liu Y; Sun H; Naeem A; Xu H; Qu Y; Wang C; Li Z; Lu J; Wang L; Wang X; Wu J; Sun L; Zhang J; Wang Z; Yang R; Wu L.
Acta Pharm Sin B (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
Adiponectin restores the obesity-induced impaired immunomodulatory function of mesenchymal stromal cells <i>via</i> gly…
Pham DV; Nguyen TK; Nguyen BL; Kim JO; Jeong JH; Choi I; Park PH.
Acta Pharm Sin B (Unknown)
Published: 2023
3/6 Transparent
Funding Declared
Mitochondria-specific near-infrared photoactivation of peroxynitrite upconversion luminescent nanogenerator for precisi…
Yu H; Tiemuer A; Yao X; Zuo M; Wang HY; Liu Y; Chen X.
Acta Pharm Sin B (Unknown)
Published: 2023
3/6 Transparent
Funding Declared